The anti-ischemic drug, Trimetazidine preserves the energy
metabolism of cells that have been exposed to ischemia or hypoxia.
Patients with angina treated with this drug showed increase coronary
flow reserve.
Doctors prescribed Trimetazidine to treat angina
pectoris. This anti-ischemic or anti-anginal metabolic drug helps
improve myocardial glucose utilization by means of inhibiting fatty acid
metabolism.
Mechanism of Action:
Referred by its
brand name, Vastarel MR, Trimetazidine is available in tablet form in
dosage of 35 milligrams. The energy metabolism of cells that are exposed
to ischemia or hypoxia can be preserved with the help of this
medication, which prevents reduction in levels of intracellular
adenosine triphosphate. The use ofthis drug ensures improved
transmembranous sodium-potassium flow and proper functioning of ionic
pumps as well as maintaining cellular homeostasis. It is also known to
inhibit oxidation of fatty acid in your blood vessels.
Important Information
Trimetazidine
should be taken with full stomach. It is not recommended to be used by
pregnant women, lactating women or people with hypersensitivity. Adverse
drug reactions to this drug include vomiting, nausea and
gastrointestinal disturbances. In some countries, Trimetazidine is
marketed as treatment for dizziness and tinnitus. This is due to the
fact that it has a high tolerability and safety profile, with no known
drug interactions.
Other Therapeutic Benefits
Trimetazidine
is also known for its cardioprotective effects as confirmed in human
ischaemia-reperfusion. The drug works on patients who are undergoing
bypass surgery with cardioplegic arrest and percutaneous coronary artery
revascularization. Studies showed that a modified-release (MR) form of
this medication, if taken twice daily, is bioequivalent to previous
formulation which is taken thrice daily.
Meanwhile, controlled
studies done on angina patients showed that Trimetazidine raises
coronary flow reserve, thus controlling rapid swings in blood pressure,
significantly decreasing the frequency of angina attacks leading to
reduction in the use of nitrates.
For diabetic patients with
coronary heart disease, Trimetazidine helps improve left ventricular
function. Trimetazidine also showed effectiveness in treating patients
with heart failure. Consulting your doctor before taking this drug is
highly recommended.
